• PMOD Kinetic Modeling Tool (PKIN)
• Introduction to Modeling in PET
  • Compartment Models
    • Model Structure
    • Input Curve
    • Calculation of the Model Curve
    • Fitting and Residual Weighting
  • Reference Tissue Models
  • Spectral Analysis (SA)
• PKIN Configuration
  • Global Configuration
  • Local PKIN Configuration
• PKIN Data Processing
  • General Assumptions in PKIN
  • Processing Overview
  • Starting the Kinetic Modeling Tool
    • User Interface
    • PKIN Menu
    • Curve Layout
    • General Curve Display Functionality
  • Data Loading/Saving
    • File-based Data Import
      • Data Units
      • Import of Blood Data
      • Import of Tissue Time-Activity Data
      • Composite Import Format for all Data (.kmData)
    • Data Import from VOIs
    • Data Saving
  • Preparation of Blood Data
    • Interpolation of Blood Data
    • Whole Blood
    • Plasma
    • Parent/Plasma Fraction
    • Default Model Configurations and Configuration Sets
  • Configuration and Fitting of Kinetic Tissue Models
    • Kinetic Model Configuration
      • Reference Models
      • Model Parameters
      • Default Model Configurations and Configuration Sets
      • Visualization of Parameter Effect
      • Parameter Restriction
      • Model Parameter Propagation/Conversion during Model Switching
      • Model Filtering
    • Kinetic Model Fitting
      • Iterative Fitting Principle
      • Fitting Options on Extras Panel
      • Residual Weighting
      • Model Fitting History
      • Fitting Problems
    • Macro Fitting
      • Macro Creation
      • Macro Execution
      • Macro Results Inspection
  • Coupled Fitting for Improving Parameter Estimates
    • Common Parameters across Regional TACs of a Single Study
    • Common Parameters across Regional TACs from Different Studies
  • Assessing Fit Results
    • Parameter Comparison across Regions (PKIN Parameters Explorer)
    • Comparison of Model Curves for a Region
    • Comparison using two PKIN Windows
    • Statistical Criteria for Comparing Models
    • Analysis of Parameter Sensitivity and Identifiability
  • Special Processing Types
    • Parameter Sensitivity to Acquisition Duration
    • Monte Carlo Simulations
    • Batch Mode
      • Batch based on Macros
      • Batch based on Model Definitions
    • Blood Delay Fitting
    • Fitting Blood Shape Parameters and Tissue Parameters together
    • Dispersion Correction for Automated Blood Samples
      • O. Munk Dispersion Correction Methodology
      • O. Munk Dispersion Calibration in PKIN
      • O. Munk Dispersion Correction in PKIN
      • Exponential Deconvolution
  • Convenience Tools
    • Changing Display Types
    • Copy Operations
    • Auxiliary Tools
    • Parameters Aggregation
  • Editing Facilities
    • Disable Measurements for Removing Outliers
    • Edit Data and Create New Curves
    • Edit Subject/Study Info and Change Isotope
    • Comments
  • Synthetic Data Generation
    • Synthetic Modeling Study for PKIN
    • Synthetic Imaging Study for PXMOD Tests
  • Modeling in Batch Pipeline
• PKIN for Regional Parametric Mapping (option)
  • Data Transfer for Parametric Mapping in PKIN
  • Voxel-wise TAC modeling in PKIN
  • Parametric Mapping Interface
    • Original Image Panel
    • Parametric Maps Panel
    • SE Maps Panel
    • Model based Image Panel
• PKIN Reference
  • Compartment Models
    • List of PKIN Compartment Models
    • 1-Tissue Compartment Model
    • 2-Tissue Compartment Model
    • 2-Tissue Compartment Model, K1/k2
    • 2-Tissue Compartment Model, K1/k2, Vs
    • 2-Tissue Compartment Model, K1/k2, Vt
    • FDG 2-Tissue Compartment Model
    • 2-Tissue Compartment Model, Linear Least Squares Method
    • Parallel 2-Tissue Compartment Model
    • 2-Tissue Compartment Model, k5
    • 2-Tissue Compartment Model, Bmax
    • 2-Tissue Compartment Model, K1/k2, Bmax
    • 2-Tissue Compartment Model with Vascular Trapping
    • 2-Tissue Compartment Model with Vascular Binding
    • Irreversible 2-Tissue Compartment Model
    • Irreversible 2-Tissue Compartment Model, Flux
    • Irreversible 2-Tissue Compartment Model, K1/k2, Flux
    • 3-Tissue Compartment Model
    • 3-Tissue Compartment Model, K1/k2, Vs
    • 3-Tissue Compartment Model, Sequential
    • 3-Tissue Compartments with Metabolites
    • 3-Tissue Compartments with Metabolites, K1/k2
    • 3-Tissue Compartments with Metabolites, K1/k2, Vs
    • 4-Tissue Compartments with Metabolites, K1/k2
    • Flumazenil Triple-injection Model
    • Water PET Model with Flow and Dispersion
  • Compartment Models for Cardiac PET
    • Cardiac Perfusion from Ammonia PET
      • Card. NH3 (de Grado)
      • Card. NH3 (UCLA, 2 Parameters)
      • Card. NH3 (2 Compartments)
      • Card. NH3 (2 Compartments, K1/k2)
    • Cardiac Perfusion from Rubidium-82 PET
      • Card. Rb-82 (1 Compartment)
      • Card. Rb-82 (2 Compartments)
    • Cardiac Perfusion from Water PET
    • Cardiac Perfusion from Acetate PET
  • Compartment Models for Cardiac SPECT
    • Cardiac Perfusion from 99mTc Tetrofosmin SPECT
  • Reference Tissue Models
    • Coupled fitting for Determination of k2' in Reference Tissue Models
    • Full Reference Tissue Model
    • Simplified Reference Tissue Model (SRTM)
    • Simplified Reference Tissue Model 2 (SRTM2)
    • Linear Simplified Reference Tissue Model (LSRTM)
    • Logan's Reference Tissue Model based on Average k2'
    • Ichise's Original Multilinear Reference Tissue Model (MRTM0)
    • Ichise's Multilinear Reference Tissue Model (MRTM)
    • Ichise's Multilinear Reference Tissue Model 2 (MRTM2)
    • Watabe's Reference Tissue Model with 2 Compartments
    • Patlak Reference Tissue Model
    • Multi-linear Reference Tissue Model for [11C]-MP4A (RLS)
  • Non-Compartmental Models
    • Logan Plot
    • Patlak Plot
    • Spectral Analysis, vB
    • Spectral Analysis SAIF
    • Ichise Multilinear Analysis MA1
    • Ichise Multilinear Analysis MA2
    • MLAIR (Multiple Linear Analysis for Irreversible Radiotracers)
    • RE-GP Analysis
    • Ito Plot
    • Partial Saturation Method, Data-driven
    • Bolus/Infusion Optimization
    • Cumulated Activity (OLINDA, IDAC)
    • Area under Curve (AUC)
    • Tissue/Plasma Ratio
    • Tissue Ratio Methods
    • Tracer Retention Fraction
    • Fractal Dimension
  • Interpolation Functions for Whole-Blood and Plasma Activity
    • Linear Activity Interpolation
    • Decaying Exponentials
    • Compartment Model with 3 Eigenvalues
    • Compartment Model with 2 Eigenvalues
    • Gamma Function
    • Gamma Function plus two Decaying Exponentials
    • Simulation of Bolus/Infusion Tracer Application
    • Flumazenil, HOT Input Curve
    • Flumazenil, COLD Input Curve
    • Calibration: Step-Up
    • Calibration: Step-Down
    • Calibration: Correction
  • Interpolation Functions for Plasma/Whole-Blood Fraction
    • Fix Plasma Fraction
    • Linear Interpolation of Plasma/Whole-blood Fraction
    • Exponential Plasma/Whole-blood Fraction
    • Hill Function
    • Watabe Function
    • Sigmoid Function
    • Linear Function
  • Interpolation Functions for Parent/Plasma Fraction
    • Fix Parent/Plasma Fraction
    • Linear Interpolation Fraction
    • 1-Exponential
    • 2-Exponentials
    • 3-Exponentials
    • Hill Function
    • Watabe Function
    • Power-Damped Exponentials
    • Sigmoid Function
• References
• PMOD Disclaimer
• PMOD Copyright Notice