Flumazenil, COLD Input Curve
The Multiinjection, COLD model is used in combination with the tissue model for multi-injection studies with 11C-Flumazenil as described by Delforge et al. . Please refer to the documentation of the implemented tissue model for a more detailed description.
It is assumed that the total plasma activity of the labeled tracer CPlasma(t) is loaded from the menu as illustrated below.
Operational Model Curve
The plasma activity of unlabeled (cold) ligand is calculated by using the information of the labeled (hot) ligand, scaling it proportionally to the applied dose, and applying the same metabolite correction. The metabolite corrected plasma activity of the labeled compound CP(t) is calculated by
The calculation of the plasma activity of the unlabeled ligand CuP(t) is also performed differently in two time segments:
Note that although the corresponding parameters have a fit box, they should normally be used for entering pre-determined values of injection times and metabolite correction parameters. The default parameters of the for the bi-exponential metabolite correction (A1, T1, A2, B2) used in this model are from .
1.Delforge J, Pappata S, Millet P, Samson Y, Bendriem B, Jobert A, Crouzel C, Syrota A: Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab 1995, 15(2):284-300. DOI