Two dedicated models have been developed for the parametric mapping of dynamic whole-body FDG PET data with variable timing of the slices:
▪Patlak analysis: It is essentially the same as the Patlak model for brain mapping, except that slice-dependent timing is allowed for and no VOI delineation is enforced.
▪Irreversible 2-tissue compartment model: This is an irreversible variant of the 2-tissue compartment model calculated using basis functions. It supports the fitting of the blood fraction as a fourth parameter, which is obtained at the cost of additional noise.
Note that depending on the reconstruction settings spatial smoothing of the data is required to obtain parametric maps. This smoothing can be configured in the loading dialog window.