Flumazenil, HOT Input Curve

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Flumazenil, HOT Input Curve

The Multiinjection, HOT model is used in combination with the tissue model for multi-injection studies with 11C-Flumazenil as described by Delforge et al. [1]. Please refer to the documentation of the implemented tissue model for a more detailed description.

It is assumed that the total plasma activity of the tracer  CPlasma(t) is loaded from the menu as illustrated below.  

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Operational Model Curve

The input curve is then calculated by applying an exponential metabolite correction which considers the two injections of hot ligand at time T1 and T3:

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Parameter Fitting

Note that although the corresponding parameters have a fit box, they should normally be used for entering pre-determined values of injection times and metabolite correction parameters. The default parameters of the for the bi-exponential metabolite correction (A1, T1, A2, B2) used in this model are from [1].

Reference

1.Delforge J, Pappata S, Millet P, Samson Y, Bendriem B, Jobert A, Crouzel C, Syrota A: Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab 1995, 15(2):284-300. DOI