PKIN implements different types of models with somewhat different properties.
Compartment Models require an input curve for the calculation of the expected concentrations in the different compartments. Most of them also support a blood spillover correction term.
Reference models do not use explicit blood information. Rather, a reference TAC is specified which must satisfy specific criteria. The reference TAC is used to calculate the response in the tissue of interest.
Non-compartment models perform different types of analyses which are not based on a compartment structure of the model. Most of them use the input curve.
Note: It is assumed that all data used has been decay corrected to the same time point.