A mechanism has been implemented in the PMOD VOI tool which allows transforming atlas VOIs into the original subject anatomy. Note, however, that the normalization procedure may fail if there is no template image available with a similar pattern than the target image, and that the resulting VOIs may need adjustment. As the normalization methods originate from the PMOD image fusion tool, please refer to its documentation for the normalization details.
The procedure is as follows:
1.Load the original image of the subject (which is not in the atlas space).
2.Select the atlas on the Template/Atlas panel (e.g. AAL-Merged).
3.Activate the Normalize button.
4.A dialog window appears to configure the normalization procedure which establishes a transformation between the subject and the atlas anatomy.
5.In the uppermost part of the window the Normalization Template can be set according to the image. In case dynamic data are analyzed, an Average frame range can be defined to be used for the normalization.
6.The algorithm performs the data normalization using the Basic and Advanced settings available in the Normalization Parameters tab. More information about the settings is available in the Deformable Registration section of the PFUSIT documentation. It calculates the inverse transformation which is then applied to the VOI atlas. Optionally, the image background can be added to VOIs if Add background as VOI checkbox is enabled.
7.Finally, the transformed VOI atlas is outlined.
The AAL atlas with grid filled overlay looks as follows:
Note the misalignment of the atlas and the image before transformation. As a result, contour VOIs appear on the List panel as illustrated below.
On the Group panel the atlas tree structure is maintained, whereas on the Template panel the atlas has been switched off